Allergies are becoming more frequent in our society. In Europe, no less than one in three people is affected and one out of two is respiratory linked. Allergic rhinitis or “hay fever” or “Pollinosis” alone affects 20 to 30% of the population.
Allergies are pathologies with a genetic predisposition but which are exacerbated by many environmental factors (called “epigenetics”), such as stress and changes in our lifestyle, rising temperatures and indoor humidity, pollution, changes in diet, the development of new medications, smoking and many other factors.
“Hay fever” or “pollinosis” is a rhinitis caused by grass pollen allergy and is often seasonal. It manifests with an itchy nose, frequent sneezing and a clear runny discharge. These disorders often come together with conjunctivitis: the eyes swell, redden and are watery. Sometimes headaches accompanied by fatigue can make you feel more uncomfortable. All symptoms of cold (except fever) can also manifest. In more severe cases, symptoms of respiratory allergy may appear: cough, difficulty breathing, or even an asthma attack.
Why and how?
When viruses enter the body, the immune system produces specific molecules that are responsible for recognizing the intruder and destroying it. In case of allergy, the body triggers a hypersensitivity reaction.
Upon contact with an allergen, the immune response leads to a high production of an antibody class, IgE (or immunoglobulin E)1. Then, these bind to the membrane of certain cells, such as mast cells. These cells are then stimulated and release significant amounts of histamine. Histamine plays an essential and vital role, in promoting the inflammatory processes necessary for the destruction of foreign bodies. Unfortunately, when the antibodies cause too much histamine to be produced, it becomes harmful and irritates the tissues to be defended.
In pollen allergy, as soon as this substance is inhaled, antibodies bound in the cells of the upper respiratory tract trigger their offensive movement, leading to the appearance of the famous hay fever or asthma attack.
The excess histamine released causes:
- Vasodilation and the formation of local edema accompanying nasal allergies.
This dilation of the blood vessels causes redness. If histamine discharge is very high, the blood is abnormally attracted to some vessels, resulting in a lack of blood in others
areas of the body: this circulatory failure can lead to anaphylactic shock,
- Smooth muscle contraction and bronchoconstriction
- Swelling of the respiratory mucous membranes, which makes it difficult to breathe normally
- It also acts on the nervous system and causes pain sensation
Finally, studies show that activation of histaminergic cells in the posterior hypothalamus produces cortical activation and causes awakening. This explains why antihistamines used against allergy have a side effect of drowsiness.
The multiple factors responsible for this allergy can be regulated by using micro minerals of trace metals: natural antihistamines!
Which minerals and trace elements to stop the allergy?
Trace elements are key elements of living organisms and play a considerable role in all biochemical exchanges that lead to the perpetuation of life. In particular, they are involved in:
- The structure of cells and tissues
- Metabolic reactions, through the different enzymatic systems that regulate these reactions
- Synthesis and action of different hormones
- The inflammatory reaction and the immune defenses, intended to protect us from aggression
- The fight against oxidative stress phenomena that alter cells and tissues
It is easy to understand that the deficiency of a single and even several trace elements, can have harmful consequences on health (2).
CALCIUM AND MAGNESIUM: NATURAL ANTIHISTAMINES
CALCIUM is the most abundant mineral in our body. Its main function is to build and renew the skeleton. Calcium also contributes to muscle and cardiac contraction, blood clotting, hormone release and nerve impulse transmission. Its involvement in cellular exchanges and membrane permeability makes it a vital element for the body.
Calcium and allergic rhinitis:
- Calcium plays an essential role in regulating the secretion of histamine. Numerous studies have shown that it intervenes both in mast cells (an exacerbated reaction to allergens) and in the histamine neurons that control the brain’s awakening centre (3).
- Calcium is essential for the activation of lymphocytes (4) (with potassium) which play a predominant role in immune defense.
Controlling calcium intake therefore makes it possible to regulate the secretion of histamine (evidence of allergy) while at the same time avoiding the risk of side effects of “drowsiness”.
It should be noted that the rate of absorption of calcium is related to magnesium intake.
In general, it can be said that wherever calcium plays a role in contraction, MAGNESIUM acts to facilitate relaxation. It is considered a natural anti-stress. It participates in more than 300 metabolic reactions in the body. According to some studies, magnesium deficiency is implicated in disorders ranging from nervousness, anxiety and fatigue to arteriosclerosis, metabolic syndrome and immune system alterations.
Magnesium and allergy:
- Many studies have shown the protective effect of magnesium on allergic reactions or asthma: the relationship between magnesium levels and histamine release is no longer necessary: it increases the activity of histidine decarboxylase, an enzyme that releases histamine from histidine (5).
- Magnesium reduces bronchoconstriction by reducing the absorption of calcium by smooth muscle cells in the bronchial tubes (6).
Controlling magnesium intake is therefore essential for regulating allergic reactions and strengthening the immune system.
ZINC and MANGANESE: STRENGTHEN THE IMMUNITY SYSTEM AND FIGHT AGAINST SYMPTOMS
The organism needs very little ZINC, but this is essential. It intervenes in the activity of more than 200 enzymes. It is involved in the structure of many hormones and metabolism of several vitamins. It is also involved in the transmission of information at the brain level and in the fight against free radicals, which generate oxidative stress.
Finally, zinc plays a fundamental role in the functioning of the immune system, as has been demonstrated by numerous studies (7).
Zinc is essential for a normal immune system function (10) and helps alleviate symptoms of allergic rhinitis
MANGANESE is found in bones (about 25% of the whole body), testicles, liver, pancreas and kidneys. It helps regulate the metabolic process of carbohydrates, in the balance of enzymatic systems and bone growth. It also ensures optimal coagulation of red blood cells. Its antioxidant properties regulate the action of free radicals.
Manganese also has an important action in immune defense.
Manganese and allergies:
- It strengthens the body’s defenses
- It helps the body to fight against cellular and tissue lesions, especially when it fights against the agents responsible for allergies (pollen type allergens).
All these faculties explain the therapeutic use of manganese, particularly to fight efficiently against allergies.
COPPER ANTI-INFECTION AND ANTI-INFLAMMATORY
COPPER is found in very small amount but essential quantities in the blood and other tissues in the cytoplasm, nucleus and mitochondria of the cell. It plays an essential role in preserving the myelin sheath of the nerves, stimulating the immune system during viral or bacterial attacks, bone growth, thyroid function and the formation of red blood cells and several hormones. It contributes to the fight against free radicals since it is the essential coenzyme of SOD (Superoxide Dismutase). This enzyme reduces oxidative damage and therefore fights against tissue ageing.
Copper is above all an anti-infectious agent, it strongly stimulates the natural defenses of immunocompromised people (11) and helps fight germs and viruses (12). In March 2008, the U. S. Environmental Protection Agency (EPA) approved copper as an antibacterial agent to control the proliferation of certain bacteria responsible for life-threatening infections (13). This action is reinforced by its ability to stimulate the production of vitamin C.
Taking only one of these trace elements do not solve any health problem. Indeed, no metabolism, even elementary, can be summed up as a single catalysis independent of the rest of the body. In addition, compounding a random combination of several trace elements can have serious repercussions. They may have different actions, depending on their combination and dilution. They interact with different mechanisms and can sometimes compete with each other: at the level of their absorption or use by the body.
Moreover, the recommended daily levels of micronutrients must be adjusted if they are blended: the association is always greater than the sum of the parts.
THE SOLUTION: Combine macros and trace elements following a specific blend carefully with very accurate ratios to create a global synergy and optimize the biocompatibility and the bioavailability.
A sequential formulation to create a global synergy and optimize the criteria for biocompatibility and bio-availability. It combines an infinitesimal dilution and a dose by weight of the various oligo-metals (calcium, magnesium, zinc, copper, manganese, sodium and potassium) to “trigger” chemical reactions inside the body to regulate and maintain the responses to the pollen allergen.
The complex acts on the disturbance of a physiological function to regulate the release of histamine, reinforce the immune system and long-term equilibrium of cellular reactions to external aggressions.
Images Credit: Pixabay
 Allergic Rhinitis, Lisa M. Wheatley, M.D., M.P.H., and Alkis Togias, M.D. N Engl J Med 2015; 372:456-463January 29, 2015DOI: 10.1056/NEJMcp1412282
 Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Maggini! S1, Wintergerst ES, Beveridge S, Hornig DH. Br J Nutr. 2007 Oct;98 Suppl 1:S29-35
 Regulatory role of calcium on histamine secretion.. Chakravarty N , Yu WJ . Agents Actions. 1986 avril; 18 (1-2): 57-60.
 Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.
Racioppi L1, Means AR. Trends Immunol. 2008 Dec;29(12):600-7. doi: 10.1016/j.it.2008.08.005. Epub 2008 Oct 17
 Magnesium levels in plasma and erythrocytes before and after histamine challenge.
Zervas E1, Loukides S, Papatheodorou G, Psathakis K, Tsindiris K, Panagou P, Kalogeropoulos N. Eur Respir J. 2000 Oct;16(4):621-5.
 Inhaled magnesium fluoride reverse bronchospasma. Gandia F, Rouatbi S, Latiri I, Guénard H, Tabka Z. J Smooth Muscle Res. 2010;46(3):157-64.
 Zinc and immune function: the biological basis of altered resistance to infection. Shankar AH, Prasad AS. Am J Clin ! Nutr. 1998; 68(suppl):447S–63S
 Effects of Zinc deficiency on immune functions. Prasad AS. J Trace Elem Exp Med 2000;13:1-20.
 Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes.
Kolenko VM1, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH. Apoptosis. 2001 Dec;6(6):419-29.
 EFSA Journal 2009;7(9):1229 « Scientific Opinion on the substantiation of health claims related to zinc and function of the immune system » (ID 291, 1757)
 Copper in microbial pathogenesis: meddling with the metal. Marie I. Samanovic,1,† Chen Ding,2,† Dennis J. Thiele,2 and K. Heran Darwin1,*
 Rudolf Steiner (voir les histoires des maladies no 113-154 dans Walter H., Les sept métaux principaux)
 EPA registers copper-containing alloy products.