The Natural and Sustainable Solution for Joint Pain

Our body is made of hundreds of very mobile but nevertheless fragile joints.
Joint pains are common and can occur at any age.

Get back to sustainable healthy joints!

Among young people, joints pains are often trauma related, mainly due to sports injury. These affect different tissues: cartilage, membranes, synovial fluid, ligaments, etc…
In children, ankle sprains, for example, represent over 15 % of injuries.

From a certain age ( between 40 and 50 years) joints suffer the consequences of ageing and the accumulation of toxins in the body. We witness the breakdown of cartilage, called osteoarthritis and hardening of certain tissues. This degeneration causes chronic pain in shoulders, elbows, wrists, hands, hips, knees, feet and back.

The term ” joint pain” includes many other disorders such as inflammatory arthritis (cartilage), gout attacks (increased uric acid), rheumatoid arthritis and ankylosing spondylitis (immune system disorders), etc.

These troubles are more or less serious, depending on their causes, their chronicity and intensity.

These pains are generally characterized by:

Variable intensity of pain that appears for no apparent reason, suddenly or gradually. It can short (days or weeks) or persistent (weeks or months)
Stiffness after a period of inactivity (especially upon waking)
Lack of flexibility
Difficulty moving and using members (loss of mobility)
– Pain in the joints during movement
Swelling, redness, warmth, general fatigue and prolonged stiffness (one hour or more) in inflammatory forms.

Age-related joint problems are considered incurable. Most of the proposed treatments, therefore, aim at relieving pain and improve joint function but they come with many side effects.
Fortunately, other alternatives are yet available:

– Adopting a healthy lifestyle to reduce toxemia and perform appropriate exercises is a great way to start.
– Choosing a natural and effective alternative to “Conventional” anti-inflammatory and analgesic treatments is even better.


The root of Harpagophytum (or Devil’s claw) plant in South Africa, is the most recommended worldwide for its analgesic and very powerful anti-inflammatory properties. It is also recognized him antispasmodic, antirheumatic and stimulating properties of the immune system.

Harpagophytum is composed of many active ingredients as harpagosides (strong anti-inflammatory and analgesic), flavonoids, phytosterols, phenols, glycosides and cinnamic acid as well as many vitamins and minerals.

Many clinical trials have documented major anti-inflammatory and analgesic action of its assets, which include proven as effective as the synthetic drugs: they allow to reduce the acidity in all joints and thus to act on integrity cartilage.

Harpagophytum, therefore, helps to significantly improve mobility and relieve pain in cases of musculoskeletal disorders: arthritis, rheumatism, back pain, tendinitis and sore back1,2. Its analgesic effect in an ideal ally in shock, accidents, and injuries3.



Turmeric is a root that contains a specific molecule curcumin used for many years in traditional medicine. This is a powerful antioxidant protecting the body from damage caused by free radicals and helping to fight against inflammation. It is also known to slow bone demineralization.

Turmeric is, therefore, a natural anti-inflammatory reference in the case of inflammatory joint pain and osteoarthritis – since it inhibits several causes of cartilage destruction. However presents a major weakness: to be effective it must be taken at a minimum dose of 1200 mg per day while it at the same time it is poorly absorbed by the body.

The TSE (Turmeric Supercritical Extract) is an extract obtained from standardized Curcuma Longa L. It is stable in pure curcumin, combining the fast analgesic action of NSAIDs with the safe use of a natural product while having an action on one of the causes of cartilage destruction and being fully absorbed by the body.

The originality of TSE, Turmeric complex lies in the technology to complex curcumin. It improves its anti -inflammatory effectiveness and ensures the assimilation of this active ingredient by the body. We then obtain a dosage bio EQUIVALENT to 1200 mg of curcumin powder for 32 mg of TSE/ Curcumin complex.

Many clinical tests have been carried on at the Research Unit on Bone and Cartilage of Liege University Hospital to prove these mechanisms of action:

– This complex of Curcuma/ TSE is a potent inhibitor of PGE2 (inflammatory mediator involved in the joint and osteoarthritis pain )
– It is a potent inhibitor of COX2 (reference iso- enzyme involved in inflammation osteoarthritis )
– It is a potent inhibitor of pro-inflammatory cytokines IL-1, IL6 and IL8 (very potent inflammatory mediators involved in inflammation and cartilage damage )
– It is a potent inhibitor of NO (potent mediator involved in the destruction of the chondrocytes is to say, the cartilage cells )
– It does not inhibit COX-1 and thereby preserves the integrity of the gastrointestinal mucosa,
– It shows no cytotoxicity and is described as having anti ulcerogenics properties favoring its long-term use.

All these results confirm the remarkable efficacy and safety of using TSE extract

This Curcuma/ TSE complex is the first fast-acting natural anti-inflammatory analgesic comparable to NSAIDs (< 1hour)


Both supplements act in synergy to stop the progression of osteoarthritis (and relieve joints). They stimulate the synthesis of new cartilage while regulating the enzymes responsible for their destruction.

Manufactured by the body from glucose and glutamine (an amino acid) GLUCOSAMINE plays a crucial role in maintaining the integrity of the cartilage of all joints. If due to a metabolic deficiency or as a result of the ageing process, the body production becomes insufficient, the cartilage begins to degenerate and osteoarthritis settles in.
Glucosamine hydrochloride appears to increase the lubricating effect of the synovial fluid, thereby slowing the degradation of cartilage, in contrast to conventional anti-inflammatory drugs which in the long term, accelerate joint degeneration4.

Several studies have been conducted and have shown that glucosamine hydrochloride reduces pain, improves mobility and accelerates healing of people with injuries to cartilage5,6. It also can act on pain due to rheumatoid arthritis7.

Chondroitin sulphate is an essential constituent of the cartilage produced naturally by the body. It is a component of cartilage connective tissues; tissues which ensure the hydration of cartilage (favoring the production of proteoglycans) and thus promoting its elasticity and flexibility8.

Chondroitin sulphate is chondroprotective :

– It supports the synthesis of cartilage cells and hyaluronic acid, a substance which imparts viscosity to the synovial fluid and lubricates between the synovium and cartilage.
– It protects the cartilage against enzymatic reactions (production of hyaluronidase) and against damage from free radicals.
– It could also inhibit osteoclasts, which are cells that play an important role in bone loss.

Chondroitin has been the subject of several meta-analyses and synthesis, which conclude on its effectiveness to relieve the symptoms of mild to moderate osteoarthritis9.

Chondroitin and glucosamine used together are particularly effective in preventing the progression of osteoarthritis since they allow to stop or slow down the degeneration of the joint tissues10.

Two American studies conducted on double-blind and controlled placebo indicate that the combined intake of glucosamine hydrochloride and chondroitin sulphate was effective in relieving symptoms of osteoarthritis of the knee11,12. The specific study GAIT (Glucosamine / Chondroitin Arthritis Intervention Trial), conducted in 2010 for 24 weeks, achieved results going in the same direction, in subjects with moderate to severe pain13.

It should be noted that the association with Tumeric “TSE” will increase the effectiveness and speed of action of it.


Consuming a complex of these active ingredients helps to prevent and improve inflammation in cases of joint pain, promote joint flexibility and maintain healthy cartilage.

But it important to select well: consuming a complex of plant extracts can be potentially dangerous and, due to the wide variation in the composition of natural products on the market, it is imperative to ensure the provenance, the dosage, and concentration of the active ingredients of some products.
On the other hand, if one can find many complexes containing dried extracts from one of the plants just mentioned above, few offer blends designed for maximum efficiency with a synergistic action.

Activa Well-Being is a unique complex, 100% natural efficient from the first dose

– It is composed of a blends of harpagophytum and turmeric complex associated with glucosamine hydrochloride and chondroitin sulphate, natural components of cartilage,
– It has anti-inflammatory and analgesic properties,
– It improves joint flexibility,
– It promotes healthy cartilage avoiding degradation and reduces the production of toxins (uric acid)
– It inhibits the progression of osteoarthritis,

The excellent tolerance of these components allows using long term without side effects,

– It acts from the first dose,
– It is made of 100% natural active with a “smart” formulation for synergistic and effective action of the components,
– It is completely bioavailable,

Biocompatible, it respects the body and acts in depth on our vitality,

Fruit of recent pharmaceutical innovations, it is presented in the form of “controlled release” microgranules to ensure a gradual release of the actives.


We’ve selected a range of supplements:

  • Made of 100% natural active ingredients
  • Completely bioavailable and biocompatible
  • In “Controlled release” microgranules form to ensure prolonged effectiveness and targeted action in the body

Images Credit: 123RF
[1] Chrubasik S, Junck H, et al. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anaesthesiol 1999 Feb;16(2):118-29.
[2] Laudahn D, Walper A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother Res 2001 Nov;15(7):621-4.
[3] Chrubasik S, Thanner J, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002 Apr;9(3):181-94.

[3] rant L, McBean DE, et al A review of the biological and potential therapeutic actions of Harpagophytum procumbens. Phytother Res. 2007 Mar;21(3):199-209.
[4] Towheed TE, Maxwell L, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002946.
[5] Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports
Med. .
[6] Glucosamine administration in athletes: effects on recovery of acute knee injury. Ostojic SM, Arsic M, et al. Res Sports Med. 2007 Apr-Jun;15(2):113-24.13.
[7] Nakamura H, Masuko K, et al. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int. 2007 Jan;27(3):213-8.
[8] J. Theodosakis. The Arthritis Cure
[9] Monfort J, Martel-Pelletier J, Pelletier JP. Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin. 2008 May;24(5):1303-8.
[10] Clegg DO et coll. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis, N Engl J Med,
354(8) : 795-808
[11] Das, A. and Hammad, T.A. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122® low molecular weight sodium chondroitin sulphate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50.
[12] Leffler CT, Philippi AF, et al. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91

legg DO, Reda DJ, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis, N Engl J Med, 2006 Feb 23;354(8):795-808.


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